In epigenetic therapy, less is more

Cell Stem Cell. 2012 Apr 6;10(4):353-4. doi: 10.1016/j.stem.2012.03.012.


How DNA methylation inhibitors exert their anticancer effects in patients is not well understood. In the latest issue of Cancer Cell, Tsai et al. (2012) use low-dose drug treatment to induce persistent attenuation of tumorigenicity by targeting tumor-initiating cells.

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