Henipavirus outbreaks to antivirals: the current status of potential therapeutics

Curr Opin Virol. 2012 Apr;2(2):176-87. doi: 10.1016/j.coviro.2012.02.016. Epub 2012 Mar 21.


The henipaviruses, Hendra virus and Nipah virus, are classic examples of recently emerged viral zoonoses. In a relatively short time since their discoveries in the mid and late 1990s, respectively, a great deal of new information has been accumulated detailing their biology and certain unique characteristics. Their broad species tropism and abilities to cause severe and often fatal respiratory and/or neurologic disease in both animals and humans has sparked considerable interest in developing effective antiviral strategies to prevent or treat henipavirus infection and disease. Here, recent findings on the few most advanced henipavirus countermeasures are summarized and discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antiviral Agents / therapeutic use*
  • Disease Outbreaks
  • Henipavirus / drug effects
  • Henipavirus / genetics
  • Henipavirus / isolation & purification
  • Henipavirus / physiology*
  • Henipavirus Infections / drug therapy*
  • Henipavirus Infections / epidemiology*
  • Henipavirus Infections / virology
  • Humans


  • Antiviral Agents