Spatially controlled carbon sponge for targeting internalized radioactive materials in human body

Biomaterials. 2012 Jul;33(20):5056-66. doi: 10.1016/j.biomaterials.2012.03.064. Epub 2012 Apr 6.


Carbon sponge, an adsorbent with spatially controlled structure is demonstrated for targeting internalized radiocesium and other radionuclides in human body. Three dimensionally ordered macroporous (3DOM) carbons derived from inverse opal replicas of colloidal-crystal template exhibit large surface area and high porosity, resulting in highly efficient adsorbents for radionuclides. It is also possible to enhance binding affinity and selectivity to radionuclide targets by decoration of 3DOM carbon surfaces with Prussian blue (PB) nanoparticles, and synthesized PB nanoparticles reveal low toxicity toward macrophage cells with potential advantages over oral administration. It is noteworthy that the maximum (133)Cs adsorption capacity of PB-decorated 3DOM carbons is 40.07 mmol g(-1) which is ca. 30 and 200 times higher than that of commercialized medicine Radiogardase(®) and bulk PB, respectively. Further, adsorption kinetics study indicates that the PB-decorated 3DOM carbons have the homogenous surface for (133)Cs ion adsorption and all sites have equal adsorption energies in terms of ion exchange between the cyano groups of the PB-decorated 3DOM carbons and radionuclides. As a concept of the oral-administrable "carbon sponge", the PB-decorated 3DOM carbons offer useful implications in the separation science of radioactive materials and important insight for designing novel materials for treatment of patients or suspected internal contamination with radioactive materials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Aged
  • Animals
  • Carbon*
  • Cell Line
  • Humans
  • Mice
  • Microscopy, Electron, Scanning
  • Microscopy, Electron, Transmission
  • Nanoparticles
  • Radioisotopes / pharmacokinetics*


  • Radioisotopes
  • Carbon