Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α

Biosci Biotechnol Biochem. 2012;76(4):847-9. doi: 10.1271/bbb.110908. Epub 2012 Apr 7.

Abstract

Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C(4) position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Sinensetin showed anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Cell Line
  • Dose-Response Relationship, Drug
  • Flavonoids / pharmacology*
  • Gene Expression / drug effects
  • I-kappa B Proteins / genetics
  • I-kappa B Proteins / metabolism*
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Inflammation / metabolism
  • Interleukin-1beta / biosynthesis
  • Interleukin-1beta / immunology
  • Interleukin-6 / biosynthesis
  • Interleukin-6 / immunology
  • Lipopolysaccharides / antagonists & inhibitors
  • Lipopolysaccharides / pharmacology*
  • Macrophages / drug effects*
  • Macrophages / immunology
  • Macrophages / metabolism
  • Mice
  • NF-KappaB Inhibitor alpha

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Flavonoids
  • I-kappa B Proteins
  • Interleukin-1beta
  • Interleukin-6
  • Lipopolysaccharides
  • Nfkbia protein, mouse
  • NF-KappaB Inhibitor alpha
  • sinensetin