Abstract
Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C(4) position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Sinensetin showed anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
-
Cell Line
-
Dose-Response Relationship, Drug
-
Flavonoids / pharmacology*
-
Gene Expression / drug effects
-
I-kappa B Proteins / genetics
-
I-kappa B Proteins / metabolism*
-
Inflammation / drug therapy
-
Inflammation / immunology
-
Inflammation / metabolism
-
Interleukin-1beta / biosynthesis
-
Interleukin-1beta / immunology
-
Interleukin-6 / biosynthesis
-
Interleukin-6 / immunology
-
Lipopolysaccharides / antagonists & inhibitors
-
Lipopolysaccharides / pharmacology*
-
Macrophages / drug effects*
-
Macrophages / immunology
-
Macrophages / metabolism
-
Mice
-
NF-KappaB Inhibitor alpha
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Flavonoids
-
I-kappa B Proteins
-
Interleukin-1beta
-
Interleukin-6
-
Lipopolysaccharides
-
Nfkbia protein, mouse
-
NF-KappaB Inhibitor alpha
-
sinensetin