Formation of supramolecular systems via directed Nucleoside-Lipid recognition

J Colloid Interface Sci. 2012 Jul 1;377(1):122-30. doi: 10.1016/j.jcis.2012.03.041. Epub 2012 Mar 22.

Abstract

We report the synthesis of a new series of Ketal Nucleoside Lipids (KNLs) featuring saturated hydrophobic double chains and either adenosine or uridine as nucleosides (KNL(A) and KNL(U), respectively). Physicochemical studies (differential scanning calorimetry, small angle X ray scattering, transmission electronic microscopy, atomic force microscopy, Langmuir isotherm, infrared spectroscopy) show that the KNLs form hydrogels below the main phase transition temperature (Tm), whereas fluid lamellar phases are obtained above T(m). Mixing complementary KNLs affords a new stable Combined Supramolecular Systems (CSSs) due to complementary A-U recognition. Molecular modeling calculations of the bilayers in a fluid state exhibit a merging of the bilayers partially due to base-base interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Lipids / chemical synthesis*
  • Lipids / chemistry
  • Macromolecular Substances / chemical synthesis
  • Macromolecular Substances / chemistry
  • Models, Molecular
  • Molecular Structure
  • Nucleosides / chemical synthesis*
  • Nucleosides / chemistry
  • Particle Size
  • Surface Properties

Substances

  • Lipids
  • Macromolecular Substances
  • Nucleosides