Electrical control of protein conformation

Adv Mater. 2012 May 8;24(18):2501-5. doi: 10.1002/adma.201200436. Epub 2012 Apr 10.


Conducting polymer devices that enable precise control of fibronectin conformation over macroscopic areas are reported. Single conformations as well as conformation gradients are achieved by applying an appropriate potential. These surfaces remain biologically relevant and support cell culture; hence, they may serve as a model to understand and control cell-surface interactions, with applications in basic research, medical diagnostics, and tissue engineering.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • 3T3 Cells
  • Animals
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry
  • Electricity*
  • Fibronectins / chemistry*
  • Fibronectins / metabolism
  • Fluorescence Resonance Energy Transfer
  • Mice
  • Polymers / chemistry
  • Protein Conformation
  • Regenerative Medicine
  • Surface Properties
  • Tissue Engineering


  • Bridged Bicyclo Compounds, Heterocyclic
  • Fibronectins
  • Polymers
  • poly(3,4-ethylene dioxythiophene)