Antihyperglycemic and antioxidative effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in mice fed with a high fat diet

Int J Mol Sci. 2012;13(3):3738-3750. doi: 10.3390/ijms13033738. Epub 2012 Mar 21.


The effect of dietary feeding of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) on the glucose metabolism and antioxidative status in mice under high fat diet conditions was investigated. The mice were randomly divided and given experimental diets for six weeks: normal control (NC group), high fat (HF group), and high fat supplemented with either HEMC (HF+HEMC group) or HPMC (HF+HPMC group). At the end of the experimental period, the HF group exhibited markedly higher blood glucose and insulin levels as well as a higher erythrocyte lipid peroxidation rate relative to the control group. However, diet supplementation of HEMC and HPMC was found to counteract the high fat-induced hyperglycemia and oxidative stress via regulation of antioxidant and hepatic glucose-regulating enzyme activities. These findings illustrate that HEMC and HPMC were similarly effective in improving the glucose metabolism and antioxidant defense system in high fat-fed mice and they may be beneficial as functional biomaterials in the development of therapeutic agents against high fat dietinduced hyperglycemia and oxidative stress.

Keywords: antioxidative effect; glucose metabolism; high fat diet; hydroxyethyl methylcellulose; hydroxypropyl methylcellulose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Blood Glucose / drug effects
  • Diet, High-Fat
  • Dietary Supplements
  • Glucose / metabolism
  • Glycogen / blood
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / pharmacology*
  • Hypromellose Derivatives / administration & dosage
  • Hypromellose Derivatives / pharmacology*
  • Insulin / blood
  • Insulin Resistance
  • Lipid Metabolism / drug effects
  • Lipid Peroxidation
  • Liver / enzymology
  • Liver / metabolism
  • Male
  • Methylcellulose / administration & dosage
  • Methylcellulose / analogs & derivatives*
  • Methylcellulose / pharmacology
  • Mice
  • Mice, Inbred C57BL
  • Oxidative Stress / drug effects
  • Weight Gain / drug effects*


  • Antioxidants
  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Hypromellose Derivatives
  • Methylcellulose
  • Glycogen
  • methyl hydroxyethyl cellulose
  • Glucose