Identification and initial characterization of a fourth leader exon and promoter of the human IGF-II gene

P Holthuizen; F M van der Lee; K Ikejiri; M Yamamoto; J S Sussenbach

doi:10.1016/0167-4781(90)90010-y

Identification and initial characterization of a fourth leader exon and promoter of the human IGF-II gene

Biochim Biophys Acta. 1990 Nov 30;1087(3):341-3. doi: 10.1016/0167-4781(90)90010-y.

Authors

P Holthuizen¹, F M van der Lee, K Ikejiri, M Yamamoto, J S Sussenbach

Affiliation

¹ Laboratory for Physiological Chemistry, State University of Utrecht, The Netherlands.

PMID: 2248982
DOI: 10.1016/0167-4781(90)90010-y

Abstract

Transcription of the human insulin-like growth factor II (IGF-II) gene is regulated by activation of multiple promoters which act in a tissue-specific and development-dependent manner. Previously, we have identified three different promoters, one of which is active in adult liver tissue only, whereas the other two are active in many fetal tissues and adult non-hepatic tissues. Here we report the identification of a fourth leader exon of the human IGF-II gene indicating the presence of a fourth promoter. Transcription from this promoter yields a 5.0 kb IGF-II mRNA species, which is detected in fetal liver and leiomyosarcoma tissue.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Base Sequence
Blotting, Northern
Exons
Gene Expression
Genes
Humans
Insulin-Like Growth Factor II / genetics*
Leiomyosarcoma / genetics
Molecular Sequence Data
Promoter Regions, Genetic*
RNA Splicing
RNA, Messenger / genetics
Rats

Substances

RNA, Messenger
Insulin-Like Growth Factor II

Associated data

GENBANK/X53038