A new player in the puzzle of filovirus entry

Nat Rev Microbiol. 2012 Apr 11;10(5):317-22. doi: 10.1038/nrmicro2764.

Abstract

Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic fever in primates, with extremely high fatality rates. Studies have focused on elucidating how these viruses enter host cells, with the aim of developing therapeutics. The ebolavirus glycoprotein has been found to play key parts in all steps of entry. Furthermore, recent studies have identified Niemann-Pick C1 (NPC1), a protein that resides deep in the endocytic pathway, as an important host factor in this process.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Carrier Proteins / metabolism*
  • Ebolavirus / pathogenicity*
  • Humans
  • Membrane Glycoproteins / metabolism*
  • Models, Biological
  • Models, Molecular
  • Receptors, Virus / metabolism
  • Viral Envelope Proteins / metabolism*
  • Virus Internalization*

Substances

  • Carrier Proteins
  • Membrane Glycoproteins
  • NPC1 protein, human
  • Receptors, Virus
  • Viral Envelope Proteins
  • envelope glycoprotein, Ebola virus