Treating ADHD with agomelatine

J Atten Disord. 2012 May;16(4):346-8. doi: 10.1177/1087054711417400.


Objective: Agomelatine is a relatively new antidepressant, with affinities to MT1 and MT2 (responsible for the circadian rhythm) as well as to 5-HT2C receptors. Since antidepressants have demonstrated some benefit in the treatment of ADH and because of the fact, that ADHD is often associated with sleep disorders, we assumed, that it might be a therapeutic alternative also for ADHD.

Method: We proved this assumption in ten ADHD patients in a placebo controlled manner.

Results: Agomelatine's effect was superior to that of placebo, but seems to be less than that of Methylphenidate or placebo.

Conclusion: If ADHD therapy with Methylphenidate or Atomoxetine is not indicated e.g. because of adverse side effects and if an ADHD patient suffers from additional sleep disorders, Agomelatine might be a helpful therapeutic alternative.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Acetamides / therapeutic use*
  • Adolescent
  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Female
  • Humans
  • Hypnotics and Sedatives / therapeutic use*
  • Male
  • Treatment Outcome
  • Young Adult


  • Acetamides
  • Hypnotics and Sedatives
  • S 20098