Axonal integrity predicts cortical reorganisation following cervical injury

J Neurol Neurosurg Psychiatry. 2012 Jun;83(6):629-37. doi: 10.1136/jnnp-2011-301875. Epub 2012 Apr 6.


Background: Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal cord-the presumed basis of ensuing clinical impairment.

Objective: The authors used a clinically viable, multimodal MRI protocol to quantify the axonal integrity of the cranial corticospinal tract (CST) and to establish how microstructural white matter changes in the CST are related to cross-sectional spinal cord area and cortical reorganisation of the sensorimotor system in subjects with traumatic SCI.

Methods: Nine volunteers with cervical injuries resulting in bilateral motor impairment and 14 control subjects were studied. The authors used diffusion tensor imaging to assess white matter integrity in the CST, T1-weighted imaging to measure cross-sectional spinal cord area and functional MRI to compare motor task-related brain activations. The relationships among microstructural, macrostructural and functional measures were assessed using regression analyses. Results Diffusion tensor imaging revealed significant differences in the CST of SCI subjects-compared with controls-in the pyramids, the internal capsule, the cerebral peduncle and the hand area. The microstructural white matter changes observed in the left pyramid predicted increased task-related responses in the left M1 leg area, while changes in the cerebral peduncle were predicted by reduced cord area.

Conclusion: The observed microstructural changes suggest trauma-related axonal degeneration and demyelination, which are related to cortical motor reorganisation and macrostructure. The extent of these changes may reflect the plasticity of motor pathways associated with cortical reorganisation. This clinically viable multimodal imaging approach is therefore appropriate for monitoring degeneration of central pathways and the evaluation of treatments targeting axonal repair in SCI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Axons / pathology
  • Axons / physiology
  • Case-Control Studies
  • Cerebral Cortex / physiopathology*
  • Cervical Vertebrae / injuries
  • Demyelinating Diseases / complications
  • Demyelinating Diseases / pathology
  • Demyelinating Diseases / physiopathology
  • Diffusion Tensor Imaging / methods
  • Diffusion Tensor Imaging / psychology
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Nerve Degeneration / pathology
  • Nerve Degeneration / physiopathology
  • Nerve Fibers, Myelinated / pathology*
  • Nerve Fibers, Myelinated / physiology*
  • Neural Pathways / pathology
  • Neural Pathways / physiopathology
  • Neuroimaging / methods
  • Neuroimaging / psychology*
  • Psychomotor Performance / physiology
  • Pyramidal Tracts / pathology
  • Pyramidal Tracts / physiopathology
  • Spinal Cord Injuries / pathology*
  • Spinal Cord Injuries / physiopathology*