"Accelerated ear-age": a new measure of chemotherapy-induced ototoxicity

Pediatr Blood Cancer. 2012 Nov;59(5):947-9. doi: 10.1002/pbc.24169. Epub 2012 Apr 10.


Currently, there are several different scales that grade chemotherapy-induced ototoxicity. This report highlights how the implications of the conclusions drawn from each scale differ and compare these prior scales to a more functionally based scale developed at Children's Hospital Boston. Additionally, this report introduces the concept of "ear-age," akin to the age at which one would expect the observed decrease in hearing as a consequence of normative aging (but documented in a child or young adult following chemotherapy).

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Child
  • Child, Preschool
  • Female
  • Hearing Loss, High-Frequency / chemically induced*
  • Hearing Loss, High-Frequency / physiopathology*
  • Humans
  • Male
  • Neoplasms, Germ Cell and Embryonal / drug therapy*