Guidelines for evaluating and managing children born with disorders of sexual development

Pediatr Ann. 2012 Apr;41(4):e1-7. doi: 10.3928/00904481-20120307-09.


Children born with disorders of sexual differentiation (DSD) pose numerous challenges for the parents, family, and treating physicians. The pediatrician is usually the first medical contact for newborns with DSD or for toddlers and children who present with DSD at a later time. Several years ago, we formed a Gender Medicine Team (GMT) at Baylor College of Medicine and Texas Children's Hospital (TCH) to explore and evaluate the most appropriate management strategies, which had long been a matter of concern and contention. Subsequently, the GMT, composed of experts in the fields of endocrinology, ethics, genetics, gynecology, psychology, pediatric surgery, and urology, formed a Task Force to evaluate the information available from our own experiences and from reviews of the literature. Utilizing the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system to assess the evidence and recommendations, the Task Force developed a consensus statement for clinical management of DSD and for making appropriate sex assignments.

Publication types

  • Practice Guideline

MeSH terms

  • Child, Preschool
  • Consensus*
  • Disorders of Sex Development / diagnosis*
  • Disorders of Sex Development / drug therapy
  • Disorders of Sex Development / genetics
  • Disorders of Sex Development / surgery
  • Humans
  • Infant
  • Texas