Clinical Comparison of the Bactec Mycosis IC/F, BacT/Alert FA, and BacT/Alert FN Blood Culture Vials for the Detection of Candidemia

Diagn Microbiol Infect Dis. 2012 Jun;73(2):153-6. doi: 10.1016/j.diagmicrobio.2012.02.020. Epub 2012 Apr 10.

Abstract

The present study analyzed the performance of Bactec Mycosis IC/F, BacT/Alert FA, and BacT/Alert FN vials in detection and time to detection (TTD) of Candida spp. in 179 simultaneous blood cultures. The Mycosis IC/F, BacT/Alert FA, and BacT/Alert FN vials could detect Candida spp. in 144 (80.45%) of 179, 149 (83.24%) of 179, and 8 (4.47%) of 179 samples, respectively. With the presence of antifungal therapy, the numbers of positive vials were higher in BacT/Alert FA compared to Mycosis IC/F, 87/99 versus 73/99, respectively (P < 0.05). TTD (SD) for C. albicans was shorter in Mycosis IC/F than in BacT/Alert FA vials without antifungal therapy, 20.89 (9.33) versus 28.26 (9.77), respectively (P < 0.01). The detection of Candida spp., with concomitant bacteremia, was higher in Mycosis IC/F than in BacT/Alert FA vials, 28/30 and 19/30, respectively (P = 0.01). The present data show that the use of Bactec Mycosis IC/F together with BacT/Alert FA vials might improve the detection of Candida spp.

Publication types

  • Comparative Study

MeSH terms

  • Antifungal Agents / therapeutic use
  • Bacteremia / blood
  • Bacteremia / microbiology
  • Candida / isolation & purification*
  • Candidemia / blood*
  • Candidemia / drug therapy
  • Candidemia / microbiology
  • Coinfection / blood
  • Coinfection / drug therapy
  • Culture Media
  • Humans
  • Limit of Detection
  • Mycological Typing Techniques / instrumentation*
  • Mycological Typing Techniques / methods*

Substances

  • Antifungal Agents
  • Culture Media