Systolic right ventricular function in children and young adults with pulmonary artery hypertension secondary to congenital heart disease and tetralogy of Fallot: tricuspid annular plane systolic excursion (TAPSE) and magnetic resonance imaging data

Congenit Heart Dis. May-Jun 2012;7(3):250-8. doi: 10.1111/j.1747-0803.2012.00655.x. Epub 2012 Apr 12.

Abstract

Objective: The tricuspid annular plane systolic excursion (TAPSE), as echocardiographic index to assess right ventricular (RV) systolic function, has not been investigated thoroughly in children and young adults with tetralogy of Fallot (TOF) and pulmonary artery hypertension secondary to congenital heart disease (PAH-CHD).

Patients: TAPSE values of 49 patients with PAH-CHD and 156 patients with TOF were compared with age-matched normal subjects. TAPSE values were also compared with RV ejection fraction (RVEF) and RV indexed end-diastolic volume (RVEDVi) determined by magnetic resonance imaging in PAH-CHD and TOF patients.

Results: Patients with a PAH-CHD showed a positive correlation between TAPSE with RVEF (r= 0.81; P < 0.001) and a negative correlation between TAPSE with RVEDVi (r=-0.67; P < 0.001). Similarly, in our TOF patients, a positive correlation between TAPSE with RVEF (r= 0.65; P < 0.001) and a negative correlation between TAPSE with RVEDVi (r=-0.42; P < 0.001) was seen.

Conclusions: Significant pressure overload in PAH-CHD patients and volume overload in TOF patients lead to a decreased systolic RV function, determined by TAPSE and magnetic resonance imaging and to increased RVEDVi values, determined by MRI, with time.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Blood Pressure
  • Cardiac Catheterization
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Echocardiography*
  • Familial Primary Pulmonary Hypertension
  • Female
  • Heart Defects, Congenital / complications
  • Heart Defects, Congenital / diagnosis*
  • Heart Defects, Congenital / diagnostic imaging
  • Heart Defects, Congenital / physiopathology
  • Humans
  • Hypertension, Pulmonary / diagnosis*
  • Hypertension, Pulmonary / diagnostic imaging
  • Hypertension, Pulmonary / etiology
  • Hypertension, Pulmonary / physiopathology
  • Infant
  • Magnetic Resonance Imaging*
  • Male
  • Observer Variation
  • Predictive Value of Tests
  • Reproducibility of Results
  • Stroke Volume
  • Tetralogy of Fallot / complications
  • Tetralogy of Fallot / diagnosis*
  • Tetralogy of Fallot / diagnostic imaging
  • Tetralogy of Fallot / physiopathology
  • Tricuspid Valve* / diagnostic imaging
  • Tricuspid Valve* / physiopathology
  • Ventricular Dysfunction, Right / diagnosis*
  • Ventricular Dysfunction, Right / diagnostic imaging
  • Ventricular Dysfunction, Right / etiology
  • Ventricular Dysfunction, Right / physiopathology
  • Ventricular Function, Right*
  • Young Adult