Developing a method to identify medicines non-adherence in a community sample of adults with epilepsy

Epilepsy Behav. 2012 May;24(1):49-53. doi: 10.1016/j.yebeh.2012.02.015. Epub 2012 Apr 10.


The aim is to propose a simple way of identifying patients at risk of antiepileptic drug (AED) non-adherence during epilepsy review (a scheduled consultation to review the patient and their condition). The use of a multi-modal approach to the problem of non-adherence is necessary because of the limitations of existing methods. A mixed methodology was developed in a nested study using a case record review to calculate the medicine possession ratio (MPR) from the AED medication records of a community sample, a literature review and a consensus panel to develop a questionnaire to address how people manage their epilepsy, particularly medicine management, and how to collect information about non-adherence through stated findings in keeping with non-adherent behavior. Results show that a medicine record can be used to estimate the MPR (<80% indicates non-adherence) and that an open and non-confrontational consultation style can be fostered by using key questions within the consultation to identify those at risk of non-adherence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Anticonvulsants / therapeutic use*
  • Epilepsy / drug therapy
  • Epilepsy / psychology*
  • Female
  • Humans
  • Male
  • Medication Adherence*
  • Middle Aged
  • Residence Characteristics
  • Surveys and Questionnaires
  • Young Adult


  • Anticonvulsants