A new range of hyaluronic acid (HA) dermal fillers has been designed using Optimal Balance Technology™, which centers around three main parameters: the degree of cross-linking, the size of gel calibration and the HA concentration. The five different products in the range (HA E Touch, HA E Classic, HA E Lips, HA E Deep and HA E Volume) have the same concentration of HA (20 mg/mL) and various degrees of cross-linking and gel calibration, in order to have distinctive physical properties adapted to their specific indications. HA E Classic, HA E Deep, HA E Lips and HA E Volume are available in two different formulations either with or without lidocaine. The efficacy, safety and patient satisfaction of the HA E range in various indications have been assessed in several classical studies. In this study, the rheological measurements of HA E Deep being the firmest gel within the range. Addition of lidocaine did not change the rheological properties of the HA E fillers. HA E fillers have three different degrees of gel calibration, with HA E Touch, HA E Classic and HA E Lips having the same smallest gel calibration and HA E Volume having the largest gel calibration within the range. Injection of all HA E fillers was smooth, regular, and required low extrusion force when using the Ultra Thin Wall (UTW)needle provided for each product. In summary, the HA E fillers have distinctive physical properties in terms of gel firmness and gel calibration, which were designed to adapt to their specific indications.