Abstract
What specific defects can cause chromosomal instability in cancer cells? Overexpression of the mitotic checkpoint protein Mad2 triggers chromosome missegregation but, surprisingly, Mad2 exerts this effect through a previously unknown effect on microtubule dynamics.
Copyright © 2012 Elsevier Ltd. All rights reserved.
MeSH terms
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Calcium-Binding Proteins / metabolism*
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Cell Cycle Proteins / metabolism*
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Chromosome Segregation*
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Kinetochores / metabolism*
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Mad2 Proteins
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Microtubules / metabolism*
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Repressor Proteins / metabolism*
Substances
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Calcium-Binding Proteins
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Cell Cycle Proteins
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MAD2L1 protein, human
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Mad2 Proteins
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Repressor Proteins