Chromosomal Instability: Mad2 beyond the spindle checkpoint

Curr Biol. 2012 Apr 10;22(7):R233-5. doi: 10.1016/j.cub.2012.02.059.

Abstract

What specific defects can cause chromosomal instability in cancer cells? Overexpression of the mitotic checkpoint protein Mad2 triggers chromosome missegregation but, surprisingly, Mad2 exerts this effect through a previously unknown effect on microtubule dynamics.

Publication types

  • Comment

MeSH terms

  • Calcium-Binding Proteins / metabolism*
  • Cell Cycle Proteins / metabolism*
  • Chromosome Segregation*
  • Kinetochores / metabolism*
  • Mad2 Proteins
  • Microtubules / metabolism*
  • Repressor Proteins / metabolism*

Substances

  • Calcium-Binding Proteins
  • Cell Cycle Proteins
  • MAD2L1 protein, human
  • Mad2 Proteins
  • Repressor Proteins