Hemostatic abnormalities and relationships to metabolic and hormonal status in polycystic ovarian syndrome

Trends Cardiovasc Med. 2011 Jan;21(1):6-14. doi: 10.1016/j.tcm.2012.01.001.


Polycystic ovarian syndrome (PCOS), diagnosed based on hyperandrogenism, ovulatory dysfunction, and polycystic ovaries, is one of the most common disorders of reproductive-aged females. Etiology includes both genetic and environmental/lifestyle factors contributing to both insulin resistance and hyperandrogenism. Clinically, PCOS has reproductive, psychological, and metabolic features, the latter predisposing to cardiovascular disease (CVD). Hemostatic abnormalities have an association with and a demonstrated pathophysiological role in CVD in non-PCOS populations but have not been adequately explored in PCOS. This review focuses on the hemostatic system in PCOS, exploring also relationships to the metabolic and hormonal abnormalities of the syndrome, and aims to identify whether hemostatic abnormalities are present as potential contributors to increased cardiovascular risk. Ultimately, this area may reveal preventative and therapeutic opportunities, which could improve the cardiovascular health of women with PCOS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control
  • Energy Metabolism*
  • Female
  • Hemostasis*
  • Hormones / blood*
  • Humans
  • Polycystic Ovary Syndrome / blood*
  • Polycystic Ovary Syndrome / diagnosis
  • Polycystic Ovary Syndrome / etiology
  • Polycystic Ovary Syndrome / physiopathology
  • Polycystic Ovary Syndrome / therapy
  • Prognosis
  • Risk Assessment
  • Risk Factors


  • Hormones