Serum and CSF measles antibody levels increase over time in patients with multiple sclerosis or clinically isolated syndrome

J Neuroimmunol. 2012 Jun 15;247(1-2):70-4. doi: 10.1016/j.jneuroim.2012.03.014. Epub 2012 Apr 11.


In general, measles virus (MV) immunoglobulin G (IgG) antibody titres decline over time. However, we found that serum and CSF MV antibody titres increased with age (slope=0.038, p<0.001 and slope=0.022, p=0.008), respectively, and disease duration (slope=0.031, p=0.002 and slope=0.032, p=0.005), respectively, in patients with multiple sclerosis (MS) or clinically isolated syndrome (CIS). The age dependency of serum antibody levels differed between patients and controls (slope=0.038 versus -0.004, p<0.001). The increasing MV antibody titres over time in MS/CIS patients support a general nonspecific stimulation of B cells and plasma cells that is not confined only to the CNS/CSF compartment.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Viral / blood*
  • Antibodies, Viral / cerebrospinal fluid*
  • Child
  • Demyelinating Diseases / blood*
  • Demyelinating Diseases / cerebrospinal fluid*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Measles / immunology*
  • Middle Aged
  • Multiple Sclerosis / blood*
  • Multiple Sclerosis / cerebrospinal fluid*
  • Time Factors
  • Young Adult


  • Antibodies, Viral