Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jun;187(6):2061-5.
doi: 10.1016/j.juro.2012.01.082. Epub 2012 Apr 11.

Prostate Specific Antigen Levels and Prostate Cancer Detection Rates in Patients With End Stage Renal Disease

Affiliations

Prostate Specific Antigen Levels and Prostate Cancer Detection Rates in Patients With End Stage Renal Disease

Catherine J Chen et al. J Urol. .

Abstract

Purpose: Patients with end stage renal disease plus prostate cancer are ineligible to receive a renal transplant at most centers until an acceptable cancer-free period is demonstrated. To our knowledge previously established prostate specific antigen reference ranges have not been validated in patients with end stage renal disease. We determined age stratified 95th percentile prostate specific antigen reference ranges and the prostate cancer detection rate at specific prostate specific antigen intervals for patients with end stage renal disease.

Materials and methods: We retrospectively reviewed the records of 775 male patients with end stage renal disease on the waiting list for a renal transplant who had undergone a serum prostate specific antigen test. Prostate specific antigen was stratified by age at the time of the blood test and 95th percentile reference ranges were calculated for each decade. A total of 80 patients underwent prostate biopsy for increased prostate specific antigen and/or abnormal digital rectal examination. The cancer detection rate was calculated for specific prostate specific antigen reference ranges.

Results: The age specific 95th percentile prostate specific antigen references ranges were 0 to 4.0 ng/ml for ages 40 to 49 in 137 patients, 0 to 5.3 ng/ml for ages 50 to 59 in 257, 0 to 10.5 ng/ml for ages 60 to 69 in 265 and 0 to 16.6 ng/ml for ages 70 to 79 years in 69. The cancer detection rate was 44%, 38% and 67% for prostate specific antigen 2.5 to 4.0, 4 to 10 and greater than 10 ng/ml, respectively.

Conclusions: In our study population of patients with end stage renal disease age stratified prostate specific antigen was higher than in the general population. The cancer detection rate was increased in our patients with end stage renal disease compared to that in patients with normal renal function at specific prostate specific antigen intervals. Lower prostate specific antigen cutoffs may be appropriate to recommend prostate biopsy in patients with end stage renal disease.

Comment in

  • Editorial comment.
    Meng M. Meng M. J Urol. 2012 Jun;187(6):2066; discussion 2066-7. doi: 10.1016/j.juro.2012.01.143. Epub 2012 Apr 11. J Urol. 2012. PMID: 22498228 No abstract available.

Similar articles

See all similar articles

Cited by 4 articles

Substances

Feedback