Molecular cytotaxonomy of primates by chromosomal in situ suppression hybridization

Genomics. 1990 Oct;8(2):347-50. doi: 10.1016/0888-7543(90)90292-3.


A new strategy for analyzing chromosomal evolution in primates is presented using chromosomal in situ suppression (CISS) hybridization. Biotin-labeled DNA libraries from flow-sorted human chromosomes are hybridized to chromosome preparations of catarrhines, platyrrhines, and prosimians. By this approach rearrangements of chromosomes that occurred during hominoid evolution are visualized directly at the level of DNA sequences, even in primate species with pronounced chromosomal shuffles.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Chromosomes, Human
  • DNA / genetics
  • Genomic Library
  • Hominidae / genetics
  • Humans
  • Nucleic Acid Hybridization*
  • Phylogeny
  • Primates / classification*
  • Primates / genetics
  • Sequence Homology, Nucleic Acid
  • Species Specificity


  • DNA