Seven patients affected by bilateral inflammatory serpiginous choroiditis have been treated with Cyclosporine-A for 6-21 months. Nine out of the fourteen eyes showed a significant improvement in their visual acuity; five eyes did not change. Cyclosporine-A may, therefore, be considered effective in the treatment of this disease. Its usefulness seems to be greater when the serpiginous choroiditis is in its 'acute' stage; 'chronic' stages, however, also seem to improve under treatment. Its main indication is, in our opinion, the involvement of the macular region of the 'second' eye, when the 'first' eye is already damaged. We consider Cyclosporine-A, in these situations, to be a first choice treatment.