The clinical spectrum of adrenocortical hyperplasia

Curr Opin Endocrinol Diabetes Obes. 2012 Jun;19(3):176-82. doi: 10.1097/MED.0b013e3283537ee9.


Purpose of review: To describe the significance of a common adrenal radiological finding on computed tomography or MRI.

Recent findings: Bilateral adrenocortical hyperplasia is the common expression of a variety of adrenal disorders, and its cause needs to be properly assessed in order to institute appropriate management.

Summary: Behind the radiological finding of bilateral adrenal enlargement, there is a spectrum of diseases that require diagnostic evaluation and management. Many cases are benign and not associated with abnormalities of endocrine function. However, these abnormalities may develop years after the initial diagnosis has been made.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenal Hyperplasia, Congenital / diagnosis*
  • Adrenal Hyperplasia, Congenital / physiopathology
  • Adrenal Hyperplasia, Congenital / therapy
  • Cushing Syndrome / diagnosis*
  • Cushing Syndrome / physiopathology
  • Cushing Syndrome / surgery
  • Disease Progression
  • Female
  • Humans
  • Hyperaldosteronism / diagnosis*
  • Hyperaldosteronism / drug therapy
  • Hyperaldosteronism / physiopathology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Mineralocorticoid Receptor Antagonists* / therapeutic use*
  • Tomography, X-Ray Computed
  • Treatment Outcome


  • Mineralocorticoid Receptor Antagonists