[Pharmacokinetics and tissue distribution of Schisandra chinensis extract in mice]

Zhong Yao Cai. 2011 Dec;34(12):1912-5.
[Article in Chinese]

Abstract

Objective: To investigate the pharmacokinetics and tissue distribution of Schisandra chinensis in mice.

Methods: Schisandrin in mice plasma and tissues including heart, liver, spleen, lung and kidney was quantitatively determined by HPLC.

Results: The concentration-time curve of Schisandra chinensis extract was described by a single compartment model, Cmax was (2.17 +/- 0.27) mg/ mL, t(max) was (1.00 +/- 0.32) h, AUC0-->infinity, was (4.07 +/- 0.62) mg x h/mL. The sequence of distribution of schisandrin in mice body was as follows: liver > plasma > kidney > lung > heart > spleen.

Conclusion: The distribution of extract in the body is abroad. Liver has relative high concentration of schisandrin, which is beneficial to the treatment of hepatic disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Area Under Curve
  • Chromatography, High Pressure Liquid / methods
  • Cyclooctanes / administration & dosage
  • Cyclooctanes / blood*
  • Cyclooctanes / pharmacokinetics*
  • Fruit / chemistry
  • Kidney / metabolism
  • Lignans / administration & dosage
  • Lignans / blood*
  • Lignans / pharmacokinetics*
  • Liver / metabolism*
  • Lung / metabolism
  • Male
  • Mice
  • Plant Extracts / blood
  • Plant Extracts / pharmacokinetics*
  • Polycyclic Compounds / administration & dosage
  • Polycyclic Compounds / blood*
  • Polycyclic Compounds / pharmacokinetics*
  • Schisandra / chemistry*
  • Spleen / metabolism
  • Tissue Distribution

Substances

  • Cyclooctanes
  • Lignans
  • Plant Extracts
  • Polycyclic Compounds
  • schizandrin