Hijacking leucyl-tRNA synthetase for amino acid-dependent regulation of TORC1

Nava Segev; Nissim Hay

doi:10.1016/j.molcel.2012.03.028

Hijacking leucyl-tRNA synthetase for amino acid-dependent regulation of TORC1

Mol Cell. 2012 Apr 13;46(1):4-6. doi: 10.1016/j.molcel.2012.03.028.

Authors

Nava Segev¹, Nissim Hay

Affiliation

¹ Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA. nava@uic.edu

Abstract

TORC1 activity in all eukaryotes is dependent on amino acid availability. However, the mechanism through which TORC1 senses amino acids is still a mystery. In the current issues of Molecular Cell and Cell, Bonfils et al. (2012) and Han et al. (2012) implicate leucyl-tRNA synthetase in this evolving story.

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