mTOR Signaling in Growth Control and Disease

Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.

Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Metabolic Diseases / metabolism
  • Neoplasms / metabolism
  • Neurodegenerative Diseases / metabolism
  • Signal Transduction*
  • Stem Cells / metabolism
  • TOR Serine-Threonine Kinases / metabolism*

Substances

  • TOR Serine-Threonine Kinases