LongoVital in the prevention of recurrent aphthous ulceration

J Oral Pathol Med. 1990 Sep;19(8):371-5. doi: 10.1111/j.1600-0714.1990.tb00862.x.


LongoVital (LV) (DK. Reg. No. 5178/75) is a herbal based tablet enriched with recommended doses of vitamins. The present study was undertaken to investigate prevention of recurrent aphthous ulceration (RAU) during 6 months' daily intake of LV as compared with placebo in a double-blind, randomized clinical, cross-over 1-yr study. The population comprised 29 otherwise healthy minor RAU patients (18 F, 11 M), mean age 36 (18-67), with an estimated average number of recurrences the previous year of 12.8 (3-30). The number of recurrences was significantly reduced on LV the latter 4 of the 6 months (P less than 0.01) where 31% were totally free of recurrences. Subjective all-over evaluation of treatment period was significantly in favor of LV. LV induced no adverse reactions and is the first harmless systemic treatment which has proved better than placebo in the prevention of RAU.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Binomial Distribution
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phytotherapy*
  • Prospective Studies
  • Recurrence
  • Stomatitis, Aphthous / prevention & control*
  • Ulcer / drug therapy
  • Vitamins / therapeutic use


  • Vitamins