Trying to make sense of retromer

Trends Plant Sci. 2012 Jul;17(7):431-9. doi: 10.1016/j.tplants.2012.03.005. Epub 2012 Apr 11.


Retromer is a cytosolic protein complex which binds to post-Golgi organelles involved in the trafficking of proteins to the lytic compartment of the cell. In non-plant organisms, retromer mediates the recycling of acid hydrolase receptors from early endosomal (EE) compartments. In plants, retromer components are required for the targeting of vacuolar storage proteins, and for the recycling of endocytosed PIN proteins. However, there are contradictory reports as to the localization of the sorting nexins and the core subunit of retromer. There is also uncertainty as to the identity of the organelles from which vacuolar sorting receptors (VSRs) and endocytosed plasma membrane (PM) proteins are recycled. In this review we try to resolve some of these conflicting observations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endocytosis
  • Hydrogen-Ion Concentration
  • Mammals / metabolism
  • Multiprotein Complexes / metabolism*
  • Plants / metabolism*
  • Saccharomyces cerevisiae / metabolism
  • Sorting Nexins / metabolism
  • trans-Golgi Network / metabolism*


  • Multiprotein Complexes
  • Sorting Nexins