Regulation of ATP production by mitochondrial Ca(2+)

Cell Calcium. 2012 Jul;52(1):28-35. doi: 10.1016/j.ceca.2012.03.003. Epub 2012 Apr 12.


Stimulation of mitochondrial oxidative metabolism by Ca(2+) is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca(2+) regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca(2+)-dependent regulation of ATP levels dynamically in single cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphate / biosynthesis*
  • Calcium / metabolism*
  • Enzymes / metabolism
  • Humans
  • Insulin-Secreting Cells / metabolism
  • Mitochondria / enzymology
  • Mitochondria / metabolism*
  • Myocytes, Cardiac / metabolism


  • Enzymes
  • Adenosine Triphosphate
  • Calcium