Correction of vitamin D deficiency improves seizure control in epilepsy: a pilot study

Epilepsy Behav. 2012 May;24(1):131-3. doi: 10.1016/j.yebeh.2012.03.011. Epub 2012 Apr 11.


There is growing interest concerning the role of vitamin D in various medical conditions such as diabetes and oncological, cardiovascular and central nervous system disorders. Although vitamin D deficiency is known to be highly prevalent among epilepsy patients, only a single study, published nearly forty years ago, assessed the effect of vitamin D on seizure control. Here, we measured serum 25-hydroxy-vitamin D (25(OH)D) levels and normalized it by administration of vitamin D3 in 13 patients with pharmacoresistant epilepsy. To see if vitamin D3 has an impact on seizure frequency, we compared seizure numbers during a 90-day period before and after treatment onset. We found that seizure numbers significantly decreased upon vitamin D3 supplementation. Median seizure reduction was 40%. We conclude that the normalization of serum vitamin 25(OH)D level has an anticonvulsant effect.

MeSH terms

  • Adult
  • Aged
  • Cholecalciferol / administration & dosage*
  • Epilepsy / blood
  • Epilepsy / diet therapy*
  • Epilepsy / etiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Treatment Outcome
  • Vitamin D / analogs & derivatives
  • Vitamin D / blood
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / complications*
  • Vitamins / administration & dosage*
  • Young Adult


  • Vitamins
  • Vitamin D
  • Cholecalciferol
  • 25-hydroxyvitamin D