miRNAs and estrogen action

Trends Endocrinol Metab. 2012 May;23(5):223-33. doi: 10.1016/j.tem.2012.03.002. Epub 2012 Apr 11.


MicroRNAs (miRNAs) are short, noncoding RNAs that generally base-pair within the 3' untranslated region of target mRNAs causing translational inhibition and/or mRNA degradation. Estradiol (E(2)) and other estrogen receptor (ER) ligands suppress or stimulate miRNA expression in human breast cancer cells, endometrial cells, rat mammary gland, and mouse uterus, and post-translationally regulate protein expression. Aberrant miRNA expression is implicated in estrogen-related breast and endometrial cancers, and several miRNAs downregulate ERα. The role of estrogen-regulated miRNA expression, the target genes of these miRNAs, and the role of miRNAs in health and disease is a 'hot' area of research that will yield new insight into molecular mechanisms of estrogen action.

Publication types

  • Review

MeSH terms

  • Animals
  • Estrogen Receptor alpha / genetics
  • Estrogen Receptor alpha / metabolism
  • Estrogens / metabolism*
  • Female
  • Humans
  • Male
  • MicroRNAs / genetics*
  • Models, Biological


  • Estrogen Receptor alpha
  • Estrogens
  • MicroRNAs