MicroRNA silencing and the development of novel therapies for liver disease

J Hepatol. 2012 Aug;57(2):462-6. doi: 10.1016/j.jhep.2012.01.030. Epub 2012 Apr 12.


In recent years microRNAs have emerged as crucial small non-coding RNA molecules with diverse roles in various diseases including diseases of the liver. In this review, we highlight the latest advances in the field of microRNA biology and their potential as emerging therapeutic targets in liver disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Dependovirus / genetics
  • Gene Silencing*
  • Humans
  • Liver Diseases / therapy*
  • MicroRNAs / antagonists & inhibitors
  • MicroRNAs / genetics*
  • Oligonucleotides, Antisense / therapeutic use


  • MicroRNAs
  • Oligonucleotides, Antisense