Atypical brain activation patterns during a face-to-face joint attention game in adults with autism spectrum disorder

Hum Brain Mapp. 2013 Oct;34(10):2511-23. doi: 10.1002/hbm.22086. Epub 2012 Apr 16.


Joint attention behaviors include initiating one's own and responding to another's bid for joint attention to an object, person, or topic. Joint attention abilities in autism are pervasively atypical, correlate with development of language and social abilities, and discriminate children with autism from other developmental disorders. Despite the importance of these behaviors, the neural correlates of joint attention in individuals with autism remain unclear. This paucity of data is likely due to the inherent challenge of acquiring data during a real-time social interaction. We used a novel experimental set-up in which participants engaged with an experimenter in an interactive face-to-face joint attention game during fMRI data acquisition. Both initiating and responding to joint attention behaviors were examined as well as a solo attention (SA) control condition. Participants included adults with autism spectrum disorder (ASD) (n = 13), a mean age- and sex-matched neurotypical group (n = 14), and a separate group of neurotypical adults (n = 22). Significant differences were found between groups within social-cognitive brain regions, including dorsal medial prefrontal cortex (dMPFC) and right posterior superior temporal sulcus (pSTS), during the RJA as compared to SA conditions. Region-of-interest analyses revealed a lack of signal differentiation between joint attention and control conditions within left pSTS and dMPFC in individuals with ASD. Within the pSTS, this lack of differentiation was characterized by reduced activation during joint attention and relative hyper-activation during SA. These findings suggest a possible failure of developmental neural specialization within the STS and dMPFC to joint attention in ASD.

Keywords: fMRI; medial prefrontal cortex; social; superior temporal sulcus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Attention / physiology*
  • Brain / physiopathology*
  • Brain Mapping*
  • Child Development Disorders, Pervasive / physiopathology*
  • Communication
  • Female
  • Games, Experimental*
  • Humans
  • Intelligence
  • Interpersonal Relations*
  • Magnetic Resonance Imaging*
  • Male
  • Prefrontal Cortex / physiopathology
  • Psychomotor Performance
  • Temporal Lobe / physiopathology
  • Video Recording
  • Young Adult