Mechanisms of protein delivery to melanosomes in pigment cells

Physiology (Bethesda). 2012 Apr;27(2):85-99. doi: 10.1152/physiol.00043.2011.


Vertebrate pigment cells in the eye and skin are useful models for cell types that use specialized endosomal trafficking pathways to partition cargo proteins to unique lysosome-related organelles such as melanosomes. This review describes current models of protein trafficking required for melanosome biogenesis in mammalian melanocytes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Endosomes / metabolism
  • Humans
  • Lysosomes / metabolism
  • Melanins / metabolism
  • Melanocytes / metabolism*
  • Melanosomes / metabolism*
  • Protein Transport


  • Melanins