Neural circuit development in the mammalian cochlea

Physiology (Bethesda). 2012 Apr;27(2):100-12. doi: 10.1152/physiol.00036.2011.


The organ of Corti, the sensory epithelium of the mammalian auditory system, uses afferent and efferent synapses for encoding auditory signals and top-down modulation of cochlear function. During development, the final precisely ordered sensorineural circuit is established following excessive formation of afferent and efferent synapses and subsequent refinement. Here, we review the development of innervation of the mouse organ of Corti and its regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cochlea / growth & development*
  • Cochlea / innervation*
  • Cochlea / ultrastructure
  • Hair Cells, Auditory / physiology
  • Humans
  • Mice
  • Neurons, Efferent / cytology
  • Neurons, Efferent / physiology
  • Synapses / physiology