Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 7 (4), e34695

Heterogeneity in Genetic Admixture Across Different Regions of Argentina

Affiliations

Heterogeneity in Genetic Admixture Across Different Regions of Argentina

Sergio Avena et al. PLoS One.

Abstract

The population of Argentina is the result of the intermixing between several groups, including Indigenous American, European and African populations. Despite the commonly held idea that the population of Argentina is of mostly European origin, multiple studies have shown that this process of admixture had an impact in the entire Argentine population. In the present study we characterized the distribution of Indigenous American, European and African ancestry among individuals from different regions of Argentina and evaluated the level of discrepancy between self-reported grandparental origin and genetic ancestry estimates. A set of 99 autosomal ancestry informative markers (AIMs) was genotyped in a sample of 441 Argentine individuals to estimate genetic ancestry. We used non-parametric tests to evaluate statistical significance. The average ancestry for the Argentine sample overall was 65% European (95%CI: 63-68%), 31% Indigenous American (28-33%) and 4% African (3-4%). We observed statistically significant differences in European ancestry across Argentine regions [Buenos Aires province (BA) 76%, 95%CI: 73-79%; Northeast (NEA) 54%, 95%CI: 49-58%; Northwest (NWA) 33%, 95%CI: 21-41%; South 54%, 95%CI: 49-59%; p<0.0001] as well as between the capital and immediate suburbs of Buenos Aires city compared to more distant suburbs [80% (95%CI: 75-86%) versus 68% (95%CI: 58-77%), p = 0.01]. European ancestry among individuals that declared all grandparents born in Europe was 91% (95%CI: 88-94%) compared to 54% (95%CI: 51-57%) among those with no European grandparents (p<0.001). Our results demonstrate the range of variation in genetic ancestry among Argentine individuals from different regions in the country, highlighting the importance of taking this variation into account in genetic association and admixture mapping studies in this population.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Distribution of genetic ancestry among 441 individuals from Argentina by four major regions.
Each individual is represented by a vertical bar on the X-axis. Bars are divided into percent European (blue), Indigenous American (red) and African ancestry (green). BA = Buenos Aires province; NEA = Northeast; NWA = Northwest; South = South. Individuals on the X-axis are sorted based on increasing Indigenous American ancestry. On the lower right corner we include a map of Argentina indicating the location of the samples. For analysis we grouped samples by region: black: BA, pink: South, grey: NWA, orange: NEA. Samples of individuals from the NEA region (orange) were obtained from the hospitals in Buenos Aires.
Figure 2
Figure 2. Box plots of average individual ancestry by four major Argentine regions.
The blue boxes represent the European component, the red boxes the Indigenous American component and the green boxes the African component. BA = Buenos Aires province; NEA = Northeast; NWA = Northwest; South = South.

Similar articles

See all similar articles

Cited by 40 PubMed Central articles

See all "Cited by" articles

References

    1. Avena SA, Goicoechea AS, Dugoujon JM, Rey J, Dejean C, et al. Mezcla genica en la Region Metropolitana de Buenos Aires. Medicina (B Aires) 2006;66:113–118. - PubMed
    1. Corach D, Lao O, Bobillo C, van Der Gaag K, Zuniga S, et al. Inferring continental ancestry of argentineans from Autosomal, Y-chromosomal and mitochondrial DNA. Ann Hum Genet. 2010;74:65–76. - PubMed
    1. Carnese FR, Avena SA, Parolín ML, Postillone MB, Dejean CR. Gene admixture estimation through genetic markers and demographic data in a sample from Buenos Aires Metropolitan Area. In: Gibbon S, Ventura Santos R, Sans M, editors. Racial Identities, Genetic Ancestry and Health in South America: Brazil, Argentina, Uruguay and Colombia. New York: Palgrave Macmillan Academic Publishers; 2011.
    1. Avena SA, Goicoechea AS, Rey J, Agosti J, Carnese FR. Analisis de la Participacion del Componente Indigena en una Muestra Hospitalaria de la Ciudad de Buenos Aires. Revista Argentina de Antropologia Biologica. 1999;2:211–225.
    1. Fejerman L, Carnese FR, Goicoechea AS, Avena SA, Dejean CB, et al. African ancestry of the population of Buenos Aires. Am J Phys Anthropol. 2005;128:164–170. - PubMed

Publication types

Feedback