Abstract
Pyrroles can serve as competent nucleophiles with meso electrophiles in the Pd-catalyzed asymmetric allylic alkylation. The products from this transformation were obtained as a single regio- and diastereomer in high yield and enantiopurity. A nitropyrrole-containing nucleoside analogue was synthesized in seven steps to demonstrate the synthetic utility of this transformation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkylation
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Allyl Compounds / chemistry*
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Catalysis
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Molecular Structure
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Nucleosides / chemical synthesis*
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Nucleosides / chemistry
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Palladium / chemistry*
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Pyrroles / chemical synthesis*
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Pyrroles / chemistry*
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Stereoisomerism
Substances
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Allyl Compounds
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Nucleosides
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Pyrroles
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Palladium