Humanized Mice: Current States and Perspectives

Immunol Lett. 2012 Aug 30;146(1-2):1-7. doi: 10.1016/j.imlet.2012.03.009. Epub 2012 Apr 9.

Abstract

The development of chimeric mice bearing the components of a human immune system to serve as animal models for "human" diseases has been the goal of many years of research. In this review we will discuss the latest advances in this field, their remaining shortcomings and challenges to the generation of new models of mouse/human chimeras.

Publication types

  • Review

MeSH terms

  • Animals
  • Chimera / genetics
  • Chimera / immunology*
  • Disease Models, Animal
  • Fetus
  • Forecasting
  • Founder Effect
  • Hematopoietic Stem Cell Transplantation
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / immunology
  • Humans
  • Immune System
  • Lymphocytes / cytology
  • Lymphocytes / immunology*
  • Mice
  • Mice, Transgenic / genetics
  • Mice, Transgenic / immunology*
  • Models, Animal*
  • Transplantation, Heterologous