Weak estrogenic transcriptional activities of Bisphenol A and Bisphenol S

Toxicol In Vitro. 2012 Aug;26(5):727-31. doi: 10.1016/j.tiv.2012.03.013. Epub 2012 Apr 5.


In 2011, the European Commission has restricted the use of Bisphenol A in plastic infant feeding bottles. In a response to this restriction, Bisphenol S is now often used as a component of plastic substitutes for the production of babybottles. One of the major concerns leading to the restriction of Bisphenol A was its weak estrogenic activity. By using two highly standardised transactivation assays, we could demonstrate that the estrogenic activity of Bisphenol A and Bisphenol S is of a comparable potency. Furthermore, some insights about the structure-activity relationships of these two chemicals and their metabolites could be gained from in silico predictions of their relative estrogen receptor-binding affinities and their liver phase-I biotransformation.

Publication types

  • Comparative Study

MeSH terms

  • Benzhydryl Compounds
  • Binding Sites
  • Cell Line, Tumor
  • Computer Simulation
  • Endocrine Disruptors / metabolism
  • Endocrine Disruptors / pharmacology*
  • Estrogen Receptor alpha / metabolism
  • Estrogens, Non-Steroidal / metabolism
  • Estrogens, Non-Steroidal / pharmacology*
  • Humans
  • Phenols / metabolism
  • Phenols / pharmacology*
  • Sulfones
  • Transcriptional Activation / drug effects


  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Estrogen Receptor alpha
  • Estrogens, Non-Steroidal
  • Phenols
  • Sulfones
  • bis(4-hydroxyphenyl)sulfone
  • bisphenol A