Lewy pathology and neurodegeneration in premotor Parkinson's disease

Mov Disord. 2012 Apr 15;27(5):597-607. doi: 10.1002/mds.24921.


The foremost motor manifestations of Parkinson's disease are resting tremor, cogwheel rigidity, hypokinesia/bradykinesia, and postural instability. Epidemiological and clinical data reveal that a wide variety of additional complaints (nonmotor symptoms), also considerably impar patients' quality of life parallel to the chronic-progressive neurodegenerative disorder. This article reviews the neuropathology and anatomy of Lewy pathology-related neurodegeneration in relation to selected nonmotro and prodromal dysfunctions.

Publication types

  • Review

MeSH terms

  • Humans
  • Lewy Bodies / pathology*
  • Lewy Body Disease / classification
  • Lewy Body Disease / metabolism
  • Lewy Body Disease / pathology*
  • Motor Neurons / pathology*
  • Neurodegenerative Diseases / classification
  • Neurodegenerative Diseases / pathology
  • Parkinson Disease / classification
  • Parkinson Disease / pathology*
  • Parkinson Disease / physiopathology