Effects of an intraoperative infusion of 4% succinylated gelatine (Gelofusine(R)) and 6% hydroxyethyl starch (Voluven(R)) on blood volume

Br J Anaesth. 2012 Aug;109(2):168-76. doi: 10.1093/bja/aes098. Epub 2012 Apr 16.


Background: This study aims to study changes in blood volume after 1 litre infusions of Gelofusine(®) [4% succinylated gelatine in 0.7% saline, weight-average molecular weight (MWw) 30 kDa] and Voluven(®) (6% hydroxyethyl starch in 0.9% saline, MWw 130 kDa) in the presence of increased capillary permeability.

Methods: In this randomized double-blind study, adults undergoing laparoscopic cholecystectomy received 1 litre of Gelofusine(®) (n=12) or Voluven(®) (n=13) over 1 h at the induction of anaesthesia. No other fluids were given. Haematocrit, serum electrolytes, and osmolality were measured before infusion and hourly thereafter for 4 h. Changes in blood volume were calculated from changes in haematocrit. The urinary albumin:creatinine ratio (ACR) was measured before and after operation.

Results: Baseline parameters before the two infusions were similar (P>0.050). The urinary ACR increased significantly after operation after Gelofusine(®) (P=0.011) and Voluven(®) (P=0.002), indicating increased capillary permeability. Voluven(®) produced a greater increase in serum chloride concentration (P=0.028) and a larger decrease in strong ion difference (P=0.009) than Gelofusine(®). There were no significant differences in changes in haematocrit (P=0.523) and blood volume (P=0.404) over the study period when the two infusions were compared, nor were there any differences in serum sodium, potassium, bicarbonate, and albumin concentrations (P>0.050). Urine output, sodium concentration, and osmolality were similar after the two infusions (P>0.050).

Conclusions: The blood volume-expanding effects of the two colloids were not significantly different, despite the increase in postoperative urinary ACR and the 100 kDa difference in MWw.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Volume / drug effects*
  • Blood Volume / physiology
  • Capillary Permeability / physiology
  • Cholecystectomy, Laparoscopic
  • Double-Blind Method
  • Electrolytes / blood
  • Female
  • Fluid Therapy / methods
  • Hematocrit
  • Hemoglobins / metabolism
  • Humans
  • Hydroxyethyl Starch Derivatives / administration & dosage
  • Hydroxyethyl Starch Derivatives / pharmacology*
  • Infusions, Intravenous
  • Intraoperative Care / methods*
  • Male
  • Middle Aged
  • Plasma Substitutes / administration & dosage
  • Plasma Substitutes / pharmacology*
  • Polygeline / administration & dosage
  • Polygeline / pharmacology*
  • Young Adult


  • Electrolytes
  • Hemoglobins
  • Hydroxyethyl Starch Derivatives
  • Plasma Substitutes
  • Polygeline