No association of genetic polymorphisms in CYP1B1 with primary open-angle glaucoma: a meta- and gene-based analysis

Mol Vis. 2012:18:786-96. Epub 2012 Mar 31.

Abstract

Purpose: To examine the effects of genetic polymorphisms in cytochrome P450, subfamily 1, polypeptide 1 (C1P1B1) on primary open-angle glaucoma (POAG).

Methods: A systematic literature search was performed, and random-effects meta-analyses were used to evaluate genetic polymorphisms in CYP1B1 with POAG. A gene-based analysis was conducted to investigate the cumulative effects of genetic polymorphisms in CYP1B1.

Results: A total of six studies from published papers were included in our analysis. Random-effects meta-analyses failed to detect any significant association of POAG with genetic polymorphisms in CYP1B1, including rs180040, rs1056836, rs10012, rs1056827, rs1056837, and rs2567206. The gene-based analysis indicated that the cumulative effect of genetic polymorphisms in CYP1B1 is not associated with POAG (p>0.50).

Conclusions: We did not find any evidence of strong association of POAG with CYP1B1 genetic polymorphisms and their cumulative effect.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Asian People / genetics*
  • Case-Control Studies
  • Cytochrome P-450 CYP1B1
  • Data Interpretation, Statistical
  • Databases, Bibliographic
  • Glaucoma, Open-Angle / genetics*
  • Humans
  • Middle Aged
  • Mutation
  • Polymorphism, Genetic*
  • White People / genetics*

Substances

  • Aryl Hydrocarbon Hydroxylases
  • CYP1B1 protein, human
  • Cytochrome P-450 CYP1B1