Layers of regulation in induction of mixed chimerism by anti-CD40L

Chimerism. Oct-Dec 2011;2(4):111-3. doi: 10.4161/chim.2.4.19053.

Abstract

The pathways regulating immunological tolerance are complex and overlapping. Here, we comment on our findings that the PD-1, CTLA-4, LAG-3 and TGFβ inhibitory molecules are all involved in mediating peripheral CD8 T‑cell tolerance induced by anti-CD40L and allogeneic bone marrow transplantation in mice. These observations suggest the possibility of targeted manipulation of these pathways for induction of mixed hematopoietic chimerism for donor-specific transplantation tolerance.

Keywords: CD8 T cells; anti-CD40L; bone marrow transplantation; mixed chimerism; tolerance.

MeSH terms

  • Animals
  • Antibodies / immunology*
  • Antigens, CD / chemistry
  • Antigens, CD / metabolism
  • Antigens, Differentiation / chemistry
  • Antigens, Differentiation / metabolism
  • Bone Marrow Transplantation / immunology
  • CD40 Ligand / immunology*
  • CD8-Positive T-Lymphocytes / immunology
  • CTLA-4 Antigen / antagonists & inhibitors
  • CTLA-4 Antigen / metabolism
  • Chimerism*
  • Mice
  • Programmed Cell Death 1 Receptor
  • Transforming Growth Factor beta / antagonists & inhibitors
  • Transforming Growth Factor beta / metabolism
  • Transplantation Tolerance / immunology
  • Transplantation, Homologous

Substances

  • Antibodies
  • Antigens, CD
  • Antigens, Differentiation
  • CD223 antigen
  • CTLA-4 Antigen
  • Pdcd1 protein, mouse
  • Programmed Cell Death 1 Receptor
  • Transforming Growth Factor beta
  • CD40 Ligand