Novel 1,2,4-triazolo[1,5-a]pyridines and their fused ring systems attenuate oxidative stress and prolong lifespan of Caenorhabiditis elegans

J Med Chem. 2012 May 10;55(9):4169-77. doi: 10.1021/jm2014315. Epub 2012 Apr 26.


In this paper we report the synthesis of some novel 1,2,4-triazolo[1,5-a]pyridine and azolotriazolopyridine ring systems. The products were screened for various types of activity like antibacterial, antifungal, and antioxidative activity. Compound 13 was found to pose an antioxidative activity. In addition, this compound was found to extend the life span of Caenorhabiditis elegans under standard laboratory conditions and reduces both heat and chemical induced oxidative stress in C. elegans in a dose-dependent manner. Furthermore, treatment of worms with compound 13 was found to significantly attenuate the formation of advanced glycation end products and malondialdehyde in a dose-dependent manner.

MeSH terms

  • Age Factors
  • Animals
  • Antioxidants / chemical synthesis*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Caenorhabditis elegans / drug effects*
  • Caenorhabditis elegans / metabolism
  • Glycation End Products, Advanced / metabolism
  • Kaplan-Meier Estimate
  • Magnetic Resonance Spectroscopy
  • Malondialdehyde / metabolism
  • Mass Spectrometry
  • Oxidative Stress / drug effects*
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry
  • Pyridines / pharmacology*
  • Spectrophotometry, Infrared
  • Triazoles / chemical synthesis*
  • Triazoles / chemistry
  • Triazoles / pharmacology*


  • Antioxidants
  • Glycation End Products, Advanced
  • Pyridines
  • Triazoles
  • Malondialdehyde