Effects of parboiled rice diet on oxidative stress parameters in kidney of rats with streptozotocin-induced diabetes

J Med Food. 2012 Jul;15(7):598-604. doi: 10.1089/jmf.2011.0306. Epub 2012 Apr 17.

Abstract

The effect of parboiled rice (PR) and white rice (WR) diets on oxidative stress (OS) parameters was investigated in the kidneys of rats with streptozotocin-induced diabetes (40 mg kg(-1), iv). The experimental groups (n=8) were control fed with PR (CPR), control fed with WR, diabetic fed with PR, and diabetic fed with WR. After 30 days of treatment, all animals were anesthetized and exsanguinated before removal of kidneys, which were used to determine thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides, carbonyl protein, superoxide dismutase, catalase, glutathione peroxidase (GPx), glutathione reductase, glutathione-S-transferase activities, and levels of glutathione (GSH). Total phenolic compounds were determined in WR and PR grains. Our data indicated that diabetes induced increase in TBARS and lipid hydroperoxides levels. Although PR has not prevented the rise in the levels of these measurements, its consumption by our animals resulted in higher GPx activity and GSH content than that of the CPR. Moreover, PR also presented concentration of total phenolic compounds 127% higher than WR grains. Thus, its consumption in this diabetic condition is suggested because this seems to confer greater protection against OS in the renal tissue of diabetic animals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants* / metabolism
  • Antioxidants* / pharmacology
  • Antioxidants* / therapeutic use
  • Cooking / methods*
  • Diabetes Mellitus, Experimental / diet therapy*
  • Diabetes Mellitus, Experimental / metabolism
  • Kidney / drug effects*
  • Kidney / metabolism
  • Lipid Peroxidation / drug effects
  • Male
  • Oryza*
  • Oxidative Stress / drug effects*
  • Phenols / analysis
  • Phenols / pharmacology
  • Phenols / therapeutic use*
  • Phytotherapy
  • Plant Preparations / pharmacology
  • Plant Preparations / therapeutic use
  • Rats
  • Rats, Wistar
  • Seeds / chemistry
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Antioxidants
  • Phenols
  • Plant Preparations
  • Thiobarbituric Acid Reactive Substances