Fraction of macroporous resin from Smilax china L. inhibits testosterone propionate-induced prostatic hyperplasia in castrated rats

J Med Food. 2012 Jul;15(7):646-50. doi: 10.1089/jmf.2011.1968. Epub 2012 Apr 17.

Abstract

The present study was conducted to evaluate the effect of a fraction of macroporous resin (FMR), a bioactive component of Smilax china L., on benign prostatic hyperplasia (BPH) in castrated rats induced by testosterone propionate. Rats were randomly divided into five groups: the negative control group (sham-operated), the model group, two FMR-treated groups (at doses of 300 mg/kg and 600 mg/kg of body weight), and the positive control group (treated with finasteride at the dose of 3 mg/kg). Drugs were administered once a day for three consecutive weeks by gastric gavage. Prostates were weighed, testosterone and dihydrotestosterone (DHT) levels in serum were determined, and histopathological examinations were carried out. FMR treatment inhibited prostatic hyperplasia, reducing the DHT level in serum and improving the prostate gland morphology compared with the model group. The overall results of this study suggest that FMR is effective at inhibiting experimentally induced prostate enlargement, and it presents a valuable resource for the treatment of human BPH.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Castration
  • Dihydrotestosterone / blood*
  • Male
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Prostate / drug effects*
  • Prostate / pathology
  • Prostatic Hyperplasia / blood
  • Prostatic Hyperplasia / chemically induced
  • Prostatic Hyperplasia / drug therapy*
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Resins, Plant*
  • Rhizome
  • Smilax*
  • Testosterone Propionate

Substances

  • Plant Extracts
  • Resins, Plant
  • Dihydrotestosterone
  • Testosterone Propionate