Clinical treatment of dry eye using 0.03% tacrolimus eye drops

Cornea. 2012 Aug;31(8):945-9. doi: 10.1097/ICO.0b013e31823f8c9b.


Purpose: To report the clinical outcome of the treatment of dry eyes using 0.03% tacrolimus eye drops (olive oil + tacrolimus 0.03%) (Ophthalmos, Sao Paulo, Brazil).

Methods: Sixteen eyes of 8 patients with Sjögren syndrome dry eyes (age, 51.13 ± 9.45 years) were enrolled in this study (prospective noncontrolled interventional case series). Patients were instructed to use topical 0.03% tacrolimus eye drops twice a day (every 12 hours) in the lower conjunctival sac. Schirmer I test, break-up time, corneal fluorescein, and rose bengal staining score were performed in all patients 1 day before, and 14, 28, and 90 days after treatment with 0.03% tacrolimus eye drops.

Results: The average fluorescein staining and rose bengal staining scores improved statistically significantly after 14 days of treatment and improved even more after 28 and 90 days. The average Schirmer I test did not improve statistically significantly after 28 days of treatment, although we did observe a significant improvement after 90 days of treatment with 0.03% tacrolimus eye drops. The average break-up time did not improve statistically after 14 days of treatment, although we observed a significant improvement after 28 and 90 days of treatment with 0.03% tacrolimus eye drops.

Conclusions: Topical 0.03% tacrolimus eye drops successfully improved tear stability and ocular surface status in patients with dry eyes.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Fluorescent Dyes
  • Fluorophotometry
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Middle Aged
  • Ophthalmic Solutions / administration & dosage
  • Prospective Studies
  • Rose Bengal
  • Sjogren's Syndrome / drug therapy*
  • Tacrolimus / administration & dosage*
  • Tears / chemistry
  • Treatment Outcome


  • Fluorescent Dyes
  • Immunosuppressive Agents
  • Ophthalmic Solutions
  • Rose Bengal
  • Tacrolimus