Biological complication in guided bone regeneration with a polylactic acid membrane: a case report

Implant Dent. 2012 Jun;21(3):171-4. doi: 10.1097/ID.0b013e31824eece1.


Purpose: This case report describes a biologic complication related to polylactic acid membrane in guided bone regeneration (GBR).

Materials and methods: A healthy 42-year-old patient complained of persistent discomfort of the maxillary anterior gingiva. Clinical examination and radiographs showed severe periodontal destruction of teeth 7 through 10. Teeth extraction was followed by early implant placement with GBR.

Results: Four months later, severe bone resorption was observed upon surgical exposure. A second GBR was performed. Wound healing progressed uneventfully and an implant-supported fixed partial denture was later loaded.

Conclusion: We presume that this complication was a foreign body reaction to the polylactic acid membrane. Such a reaction can affect soft and hard tissue healing following GBR. Long-term follow-up is needed to determine stability of the results.

Publication types

  • Case Reports

MeSH terms

  • Absorbable Implants / adverse effects*
  • Adult
  • Alveolar Bone Loss / etiology*
  • Alveolar Bone Loss / surgery
  • Bone Regeneration
  • Dental Prosthesis, Implant-Supported
  • Denture, Partial, Fixed
  • Foreign-Body Reaction / etiology*
  • Guided Tissue Regeneration, Periodontal / methods*
  • Humans
  • Lactic Acid / adverse effects*
  • Membranes, Artificial
  • Polyesters
  • Polymers / adverse effects*


  • Membranes, Artificial
  • Polyesters
  • Polymers
  • Lactic Acid
  • poly(lactide)