Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Mar;70(3):421-6.

[Radiation Induced Carcinogenesis]

[Article in Japanese]
Affiliations
  • PMID: 22514919
Review

[Radiation Induced Carcinogenesis]

[Article in Japanese]
Toshiya Inaba. Nihon Rinsho. .

Abstract

Intense research after Hiroshima and Nagasaki atomic bomb (A-bomb) tragedy and Chernobyl nuclear plant accident revealed that ionizing radiation (IR) more than 100 mSv induces cancers that are indistinguishable from sporadic tumors. It remains controversial whether low dose IR (less than 100 mSv) is oncogenic or not. Among IR-induced malignancies, leukemia (A-bomb) and thyroid cancers (Chernobyl), in which chimeric(fusion) oncogenes formed by chromosome translocations play a critical role, develop with relatively short latency. All other cancers develop after long latency. Age-related epigenetic changes, as well as additional genetic alterations, would contribute to IR-induced carcinogenesis.

Similar articles

See all similar articles

MeSH terms

Feedback